posted on 2024-01-05, 07:14authored byYufeng Li, Shanqi Chen, Mingdong Zhang, Xiang Ma, Jian Zhao, Yuanhui Ji
Multivalent
ion cross-linking has been used to form hydrogels between
sodium alginate (SA) and hyaluronic acid (HA) in previous studies.
However, more stable and robust covalent cross-linking is rarely reported.
Herein, we present a facile approach to fabricate a SA and HA hydrogel
for wound dressings with injectable, good biocompatibility, and high
ductility. HA was first reacted with ethylenediamine to graft an amino
group. Then, it was cross-linked with oxidized SA with dialdehyde
to form hydrogel networks. The dressing can effectively promote cell
migration and wound healing. To increase the antibacterial property
of the dressing, we successfully loaded tetracycline hydrochloride
into the hydrogel as a model drug. The drug can be released slowly
in the alkaline environment of chronic wounds, and the hydrogel releases
drugs again in the more acidic environment with wound healing, achieving
a long-term antibacterial effect. In addition, one-dimensional partial
differential equations based on Fickian diffusion with time-varying
diffusion coefficients and hydrogel thicknesses were used to model
the entire complex drug release process and to predict drug release.