A nitrogen-centered radical-mediated
strategy for preparing 1,2-trans-2-amino-2-deoxyglycosides
in one step was established.
The cascade amidoglycosylation was initiated by a benzenesulfonimide
radical generated from NFSI under the catalytic reduction of TEMPO.
The benzenesulfonimide radical was electrophilically added to the
glycals, and then the resulting glycosidic radical was converted to
oxocarbenium upon oxidation by TEMPO+, which enabled the
following anomeric specific glycosylation.