New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity

Peng, Jing; Zhang, Qingbo; Jiang, Xiaodong; Ma, Liang; Long, Ting; Cheng, Ziqian; Zhang, Changsheng; Zhu, Yiguang

doi:10.6084/m9.figshare.14247243.v2

gnpl_a_1901699_sm7402.pdf (2.27 MB)

New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity

Version 2 2021-03-30, 13:00

Version 1 2021-03-19, 08:20

journal contribution

posted on 2021-03-30, 13:00 authored by Jing Peng, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Ting Long, Ziqian Cheng, Changsheng Zhang, Yiguang Zhu

Two new piericidins A5 (1) and G1 (2), a previously synthesized piericidin G2 (3), and two known piericidins A1 (4) and A2 (5) were isolated from the marine-derived Streptomyces sp. SCSIO 40063. The structures of 1-5 were elucidated by HRESIMS, 1 D, 2 D NMR data analyses and comparisons with the known compounds. Compound 2 showed moderate cytotoxicities against four human tumor cell lines SF-268, MCF-7, HepG2 and A549 with IC₅₀ values between 10.0 and 12.7 μM.