posted on 2019-09-23, 15:39authored byR Ashkar, HZ Bilheux, H Bordallo, R Briber, DJE Callaway, X Cheng, XQ Chu, JE Curtis, M Dadmun, P Fenimore, D Fushman, F Gabel, K Gupta, F Herberle, F Heinrich, L Hong, J Katsaras, Z Kelman, E Kharlampieva, GR Kneller, A Kovalevsky, S Krueger, P Langan, R Lieberman, Y Liu, M Losche, E Lyman, Y Mao, J Marino, C Mattos, F Meilleur, P Moody, JD Nickels, WB O'Dell, H O'Neill, U Perez-Salas, J Peters, L Petridis, AP Sokolov, C Stanley, N Wagner, M Weinrich, K Weiss, T Wymore, Y Zhang, JC Smith
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.
Funding
The authors thank the National Science Foundation for
funding the workshop that led to this article. The workshop
was chaired by Jeremy C. Smith and Mark Dadmun. The
attendees thank Adam Green and Lora Davis for logistical
support. This manuscript has been authored by UT-Battelle
LLC under Contract No. DE-AC05-00OR22725 with the US
Department of Energy. The United States Government retains
and the publisher, by accepting the article for publication,
acknowledges that the United States Government retains a
non-exclusive, paid-up, irrevocable, worldwide license to
publish or reproduce the published form of this manuscript, or
allow others to do so, for United States Government purposes.
The Department of Energy will provide public access to these
results of federally sponsored research in accordance with the
DOE Public Access Plan (http://energy.gov/downloads/
doe-public-access-plan).