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Neutralization of various BG505 virus variants.

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posted on 2021-08-25, 17:39 authored by Jelle van Schooten, Marlies M. van Haaren, Hui Li, Laura E. McCoy, Colin Havenar-Daughton, Christopher A. Cottrell, Judith A. Burger, Patricia van der Woude, Leanne C. Helgers, Ilhan Tomris, Celia C. Labranche, David C. Montefiori, Andrew B. Ward, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Shane Crotty, George M. Shaw, Marit J. van Gils

To map the epitopes of the NAbs, we performed neutralization assays with a variety of virus variants. For each mAb, the IC50 value against each pseudovirus variant relative to the BG505.T332N parental virus is given. This value is indicated as the relative inhibitory concentration 50 (RIC50). If the NAbs were unable to neutralize a virus variant, the value indicates the IC50 divided by the highest concentration that was used in the assay that gave no neutralization.

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    PLOS Pathogens

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    prolonged antigenic stimulationinduce better responsesdiverse epitopes comparedanalyzing monoclonal antibodiesincreased antigen diversityinduced antibody responsesenv ), includingdiv >< pantibody responses induced1 envelope trimersstudying bnab developmentinform vaccine designprototypic bg505 sosipshiv infection resultedsoluble native hivbg505 shiv infectionbg505 sosip immunizationsoluble nativesosip designantibody responseextreme diversitybnab responsebg505 shivbg505 sosipshiv infectionbg505 envsosip immunizationnatural infection1 infectionvirus membranevaccine needsvaccine candidatesshown promisesequence isolatedplaced ontonatural hivmabs ).like hivlatter settinginfected infantinfected animalsimmunized animalshuman primatesextent vaccineenv either elicitedclonal expansionautologous virusanimal models664 immunogen1 ’

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