pone.0251957.s006.pdf (1.86 MB)
Neurosphere formation assay.
journal contribution
posted on 2021-11-03, 17:25 authored by Riccardo Serra, Tianna Zhao, Sakibul Huq, Noah Leviton Gorelick, Joshua Casaos, Arba Cecia, Antonella Mangraviti, Charles Eberhart, Renyuan Bai, Alessandro Olivi, Henry Brem, Eric M. Jackson, Betty TylerNeurosphere formation was greatly reduced after 72 hours of treatment with 150nM DSF-Cu++ in D425med and D341 cells. High-Dose DSF-Cu++ reduces ALDH+ cancer cells in D425med and D341 lines. 2uM DSF-Cu++ induces significant reduction in ALDH+ cells in D425med and D341 after 2 hours of treatment.
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sup >+sup >++common brain malignancytp53m ), d425mednpl4 ), ki67combination may servegroup 3 mbcancer stem cellsnpl4 accumulationgroup 3xlink ">vivo vitro ubiquitylated proteinsstill responsiblenovel treatmentneun expressionnanomolar concentrationsmolecular mechanismshuman sshfollowing treatmentexisting therapiesdsf ),dna damagedata suggestclonogenic assaysapproved inhibitoraldh ),aggressive subtypes
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