posted on 2023-02-08, 17:03authored byJesus Rodrigalvarez, Hao Wang, Ruben Martin
Herein, we disclose an interrupted
deaminative Ni-catalyzed
chain-walking
strategy that forges sp3–sp3 architectures at remote, yet previously unfunctionalized,
methylene sp3 C–H sites enabled by the presence
of native amides. This protocol is characterized by its mild conditions
and wide scope, including challenging substrate combinations. Site-selectivity
can be dictated by a judicious choice of the ligand, thus offering
an opportunity to enable sp3–sp3 bond formations that are otherwise inaccessible in conventional
chain-walking events.