posted on 2021-07-27, 09:13authored byZeyu Xiao, Yuanyuan You, Yiyong Liu, Lizhen He, Dong Zhang, Qingqing Cheng, Dan Wang, Tianfeng Chen, Changzheng Shi, Liangping Luo
Escorting
therapeutics for malignancies by nano-encapsulation to
ameliorate treatment effects and mitigate side effects has been pursued
in precision medicine. However, the majority of drug delivery systems
suffer from uncontrollable drug release kinetics and thus lead to
unsatisfactory triggered-release efficiency along with severe side
effects. Herein, we developed a unique nanovesicle delivery system
that shows near-infrared (NIR) light-triggered drug release behavior
and minimal premature drug release. By co-encapsulation of superparamagnetic
iron oxide (SPIO) nanoparticles, the ultrasound contrast agent perfluorohexane
(PFH), and cisplatin in a silicate-polyaniline vesicle, we achieved
the controllable release of cisplatin in a thermal-responsive manner.
Specifically, vaporization of PFH triggered by the heat generated
from NIR irradiation imparts high inner vesicle pressure on the nanovesicles,
leading to pressure-induced nanovesicle collapse and subsequent cisplatin
release. Moreover, the multimodal imaging capability can track tumor
engagement of the nanovesicles and assess their therapeutic effects.
Due to its precise inherent NIR-triggered drug release, our system
shows excellent tumor eradication efficacy and biocompatibility in vivo, empowering it with great prospects for future clinical
translation.