pgen.1011012.s016.pdf (38.22 kB)
Mutation rate estimated by fluctuation assay in wildtype and four additional mutators in BY genetic background with genes responsible for DNA repair or stress response deleted.
journal contribution
posted on 2023-11-06, 18:30 authored by Jing Li, Simon Stenberg, Jia-Xing Yue, Ekaterina Mikhalev, Dawn Thompson, Jonas Warringer, Gianni LitiEach strain had 16 replicates. The error bar represents 95% confidence intervals.
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mutational processes dictatingincluding mtdna deletionsresolved growth phenotypinghydroxyurea also inducedmutation rates dependedparticularly high occurrencehydroxyurea mutation footprintgenome instability footprintdramatic fitness lossmutation ratescell growthxlink ">wide rangeused wholetransversion ratetaken togetherstudy providesstructural variantsremarkable exceptionmutagenic effectsmarginally affectedimportant implicationsgenome sequencinggenetic backgroundsgenetic backgroundgave riseelevated regardlessdisease treatmentdetailed viewdepth viewchronic effectscell fitnessbroad rangebrings insightsaccurate quantification
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