Molecular basis of Broken-reentrant helix transition.

(a) Density plot showing the hydrophobicity of broken and reentrant helices belonging to the three fold-types. (b) Density plot for KR-bias of the last helix of the N- and C-terminal core subdomain belonging to three fold-types. N_in and N_out core subdomains of the three fold-types are shown as cartoon representations. The last helix shows the change in orientation. N_in and N_out denote the orientation of the first helix of the core subdomain. (c) The first four figures show the N- and C-terminal core subdomains of the broken and reentrant transporter. The last helix is shown dark while the other two helices are shown in transparent colour. The final figure shows the structure superimposition between the broken and reentrant core domains.

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