mz1c00643_si_001.pdf (649.79 kB)
Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles
journal contribution
posted on 2022-01-29, 02:03 authored by Yasuhiro Nakagawa, Jeonggyu Lee, Yihua Liu, Saed Abbasi, Taehun Hong, Horacio Cabral, Satoshi Uchida, Mitsuhiro EbaraPhosphatidylserine
(PtdSer), one of the phospholipids that the
apoptotic cell exposes, has emerged for anti-inflammatory therapy via polarizing inflammatory microglia (Mi1) to anti-inflammatory
phenotype (Mi2). In this study, we report microglia polarization effect
of PtdSer-exposing polymeric particles (PSPs). PSPs upregulated Mi2
microglia and suppressed Mi1 microglia through peroxisome proliferator-activated
receptor gamma upregulation in vitro and in vivo. This study highlights the potential of PSPs for
anti-inflammatory therapy.
