pone.0257186.s006.docx (20.13 kB)
Metformin effect on steroid hormones in children from the PregMet study, unadjusted, and adjusted for BMI z-score.
journal contribution
posted on 2021-09-09, 17:29 authored by Liv Guro Engen Hanem, Øyvind Salvesen, André Madsen, Jørn V. Sagen, Gunnar Mellgren, Petur Benedikt Juliusson, Sven Magnus Carlsen, Eszter Vanky, Rønnaug Ødegård(DOCX)
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findings need confirmationcommon endocrine disorderameliorate hormonal disturbancesaltered intrauterine environment14 &# 821132 ), p06 ), p00 ), pintrauterine metformin exposure255 children invitedage adjusted zxlink "> girlsstudy &# 8211offspring endocrine developmentnorwegian reference populationmean difference 0maternal pcos status5 &# 8211higher mean z17 ), pmetformin versus placebo0001 ), testosteronexlink ">reference population0001 ),exposed childrenchildren bornsteroid hormonesserum levelspregnant womenpotential effectspotential consequencespcos pregnanciespcos cannotold daughtersincreasingly usedincreased riskinclude participantshigher 11free testosteroneexposed boyselevated androgensdeveloping pcosconfidence intervalbonferroni adjustments46 %)2000 mg
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