Meta-analysis: impact of intragastric balloon therapy on NAFLD-related parameters in patients with obesity
Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease affecting approximately 25% of adults in the western world. Intragastric balloon (IGB) is an endoscopic bariatric therapy -a therapeutic endoscopic tool that has shown promise in inducing weight loss. Its role in the treatment of NAFLD is yet to be established.
Aim: To evaluate the effect of IGB as a treatment option in NAFLD.
Methods: We searched MEDLINE (PubMed) and EMBASE from inception to September 2022. We included studies evaluating the impact of IGB on obesity with the assessment of one or more liver-related outcomes and studies primarily evaluating the impact of IGB on NAFLD. We included comparative and non-comparative studies; primary outcomes were liver-related NAFLD surrogates.
Results: We included 19 studies with 911 patients. IGB demonstrated an effect on NAFLD parameters including NAFLD activity score (NAS): mean difference (MD): -3.0 [95% CI: -2.41 to -3.59], ALT: MD: -10.40 U/L [95% CI: -7.31 to -13.49], liver volume: MD -397.9 [95% CI: -212.78 to 1008.58] and liver steatosis: MD: -37.76 dB/m [95% CI: -21.59 to -53.92]. There were significant reductions in non-liver-related outcomes of body weight, BMI, glycated haemoglobin and HOMA-IR.
Conclusion: Intragastric balloons may play an important role in addressing the treatment gap in NAFLD management.
Funding
Charitable Infirmary Charitable Trust—Kieran Taaffe Bursary
Beaumont Hospital Dublin
Royal College of Surgeons in Ireland
Open access funding provided by RCSI
History
Comments
The original article is available at https://onlinelibrary.wiley.com/Published Citation
Aoko O, Maharaj T, Boland F, Cheriyan D, Ryan J. Meta-analysis: impact of intragastric balloon therapy on NAFLD-related parameters in patients with obesity. Aliment Pharmacol Ther. 2023;59(1):8-22.Publication Date
20 November 2023External DOI
PubMed ID
37986213Department/Unit
- Beaumont Hospital
- Medicine
Publisher
John Wiley & Sons, IncVersion
- Published Version (Version of Record)