Mendelian randomisation of retinal layers and intraocular pressure.
(A) Scatter plot of the relationship between the effect size of SNPs found significantly associated with GCIPL thickness, and the effect size of those SNPs on IOP. (B) Forest plot showing the effect size and direction of SNPs significantly associated with GCIPL thickness on IOP. (C) Scatter plot of the relationship between the effect size of SNPs found significantly associated with RNFL thickness, and the effect of those SNPs on IOP. (D) Forest plot showing the effect size and direction of SNPs significantly associated with RNFL thickness on IOP. (E) Scatter plot of the relationship between the effect size of SNPs found significantly associated in the meta-analysed GCIPL and RNFL thicknesses, and the effect of those SNPs on IOP. (F) Forest plot showing the effect size and direction of SNPs significantly associated in the meta-analysed GCIPL and RNFL thickness on IOP. Summary statistics for genetic association studies of IOP, were taken from [1]. References [1] Khawaja, A. P. et al. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nature Genetics 50, 778–782 (2018).
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