ppat.1010002.s008.docx (230.56 kB)
Mathematical approach to estimate mRNA:leaderRNA ratios in EBOV-infected HuH7 cells.
journal contribution
posted on 2021-10-26, 17:31 authored by Simone Bach, Jana-Christin Demper, Paul Klemm, Julia Schlereth, Marcus Lechner, Andreas Schoen, Lennart Kämper, Friedemann Weber, Stephan Becker, Nadine Biedenkopf, Roland K. Hartmann(DOCX)
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segmented negative senseprovide evidence arguing60 – 803 ’- endpromoter elements 1cryptic gene endspecifically initiated oppositediv >< ptrailer rnas synthesizedrna viruses followstranscription versus replicationgenome nt 2trailer promoter recognitiongenome ’first genetransfected cellstranscription modetranscription initiationtranscription complexestaken togetherstart mechanismshort leaderseparate sitessecond nucleotiderna initiationpredominantly terminatedpotential rolent 2nns virusesmodel accordinglength variationleader innate immunityeffector moleculesebola viruse .,48 h
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