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Macroevolutionary diversity of traits and genomes in the model yeast genus Saccharomyces

journal contribution
posted on 2022-11-24, 10:01 authored by David PerisDavid Peris

 Species is the fundamental unit to quantify biodiversity. In recent years, the model yeast Saccharomyces cerevisiae has seen an increased number of studies related to its geographical distribution, population structure, and phenotypic diversity. However, seven additional species from the same genus have been less thoroughly studied, which has limited our understanding of the macroevolutionary events leading to the diversification of this genus over the last 20 million years. Here, we show the geographies, hosts, substrates, and phylogenetic relationships for approximately 1,800 Saccharomyces strains, covering the complete genus with unprecedented breadth and depth. We generated and analyzed complete genome sequences of 163 strains and phenotyped 128 phylogenetically diverse strains. This dataset provides insights about genetic and phenotypic diversity within and between species and populations, quantifies reticulation and incomplete lineage sorting, and demonstrates how gene flow and selection have affected traits, such as galactose metabolism. These findings elevate the genus Saccharomyces as a model to understand biodiversity and evolution in microbial eukaryotes. 

 Assemblies, raw data, scripts and command lines to perform analyses are described in


BCV-2021-1-0001 - University of Valencia

CIDEGENT/2021/039 - Generalitat Valenciana

RCN 324253 - Research Council of Norway

RCN 274337 - Research Council of Norway

DGE-1256259 - National Science Foundation

5T32GM007133 - National Institutes of Health

Great Lakes Bioenergy Research Center

Office of Biological and Environmental Research

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Great Lakes Bioenergy Research Center

Office of Biological and Environmental Research

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Generating yeast biodiversity by mitochondrial introgression for wine innovation

European Commission

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DEB-2110403 - National Science Foundation

1020204 - USDA National Institute of Food and Agriculture Hatch

Illumina Abstract Competition - Illumina Inc


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