MHC-I PHBR analysis using common and rare HLA alleles from different populations.

PHBR scores were calculated considering different MHC-genotypes as indicated. Box plots compare PHBR scores between observed (+) and unobserved (-) mutations. Mutations were derived from the virtual patient mutation matrix used in the main analysis. (A) MHC-I genotype composed of the 2 most frequent HLA-A, HLA-B and HLA-C alleles for different populations from the 1000 genomes project. (B) MHC-I genotype composed of 2 random HLA-A, HLA-B and HLA-C alleles that were never observed in the indicated population. Box plots show median values and lower/upper quartiles with whiskers extending to 1.5 times the interquartile range. P values calculated using Wilcoxon rank-sum test. AFR, African; AMR, Ad Mixed American; EAS, East Asian; EUR, European; SAS, South Asian.

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