ja1c07162_si_001.pdf (12.52 MB)
Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes
journal contribution
posted on 2021-09-09, 13:06 authored by Tanner
C. Jankins, Raul Martin-Montero, Phillippa Cooper, Ruben Martin, Keary M. EngleA tungsten-catalyzed hydroboration
of unactivated alkenes at distal
C(sp3)–H bonds aided by native directing groups
is described herein. The method is characterized by its simplicity,
exquisite regio- and chemoselectivity, and wide substrate scope, offering
a complementary site-selectivity pattern to other metal-catalyzed
borylation reactions and chain-walking protocols.