Longitudinal Impacts of PM_2.5 Constituents on Adult Mortality in China

Limited evidence exists for long-term effects of PM_2.5 constituents on mortality. Hence, we aimed to assess associations between all-cause mortality and long-term exposure to PM_2.5 constituents in China. We designed a nationwide cohort study of 30524 adults from 162 prefectural areas across mainland China with follow-ups through years 2010–2017. Cox proportional hazards models with time-varying exposures were employed to quantify associations between all-cause mortality and long-term exposure to PM_2.5 and constituents. A total of 1210 deaths occurred during 172297.7 person-years. A multiadjusted Cox model estimated an hazard ratio (HR) of 1.125 (95% confidence interval: 1.058–1.197) for all-cause mortality, associated with an interquartile range (IQR = 26.7 μg/m³) rise in exposure to PM_2.5. Comparable or stronger associations were found among PM_2.5 constituents with the mortality risk increased by 11.3–14.1% per IQR increase in exposure concentrations. After adjustment for the collinearity between total PM_2.5 and constituents, effect estimates for nitrate, ammonium, and sulfate remained significant and became larger. Urban residents, alcohol drinkers, smokers, and men were more susceptible to chronic impacts from ambient PM_2.5 constituents. This cohort study added the novel longitudinal evidence for elevated mortality linked with long-term exposure to PM_2.5 constituents among Chinese adults.