pone.0298802.s003.docx (19.32 kB)
Log2FC values of ECM proteins and integrins for each segment in high and low outflow regions of TM.
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posted on 2024-02-23, 18:43 authored by Jennifer A. Faralli, Mark S. Filla, Yong-Feng Yang, Ying Ying Sun, Kassidy Johns, Kate E. Keller, Donna M. PetersLog2FC values of ECM proteins and integrins for each segment in high and low outflow regions of TM.
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α8 integrin subunittranscriptome analyses revealedlog2fc ± 1integrin signaling (<digital spatial profilingunderstanding segmental flowspatial transcriptomics approachimmunolabeling studies supporteddiv >< ptwo genes associatedlow outflow regionsdifferentially expressed genestrabecular meshwork revealssegmental outflow regionslargest differential expressionhigh outflow regionscell adhesion genesadam15 segmental outflowtrabecular meshworkcell adhesionuseful approachdifferential expression57 genes16 genesldb3 crkl bgn adam15 thus demonstratingstudies showedsmall leucinesignal transductionschlemm ’key playersinner walleither highcrkl )
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