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Labdane Diterpenoid Glycosides from Alpinia densespicata and Their Nitric Oxide Inhibitory Activities in Macrophages

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journal contribution
posted on 2009-06-26, 00:00 authored by Yu-Jen Kuo, Ping-Chun Hsiao, Li-Jie Zhang, Ming-Der Wu, Yu-Han Liang, Hsiu-O Ho, Yao-Haur Kuo
Four new labdane diterpene glycosides (14) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (79) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 16 was based on spectroscopic data. Compounds 19 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μM against several human tumor cell lines.