Iron-Catalyzed Regioselective Reductive Fluoroalkylalkenylation of Unactivated Alkenes

The example of iron-catalyzed reductive fluoroalkylalkenylation of unactivated alkenes has been disclosed, affording the stereodefined homoallylic fluoroalkanes with high efficiency and regioselectivity. This three-component cross-electrophile coupling features directing groups free, good functional group tolerance, broad substrate scope, and late-stage difunctionalization of biorelevant molecules. Moreover, this protocol sheds light on the distinct reactivity disparities between fluoroalkyl and nonfluoroalkyl radicals in three-component reductive cross-coupling reactions, highlighting the unique nature of iron/B₂pin₂ systems.