posted on 2021-08-24, 20:43authored byJinhu Wei, Jie-Sheng Huang, Chi-Ming Che
A chiral FeII(N4) complex
(N4 = (R,R)-N,N′-bis(2-isopropylquinolin-8-yl)-1,2-diphenylethane-1,2-diamine)
was developed for the asymmetric conjugate addition of silyl enol
ethers, including both acyclic ones and cyclohexenone-derived ones,
to α,β-unsaturated 2-acyl imidazoles. This FeII complex is an effective chiral Lewis acid and was applied in the
synthesis of an array of chiral 1,5-dicarbonyl synthons and cyclohexenone
derivatives with high yields and enantioselectivities (up to 99% ee).