posted on 2021-06-29, 14:38authored byPanchi Guo, Miao Zhan
An iridium-catalyzed enantioconvergent coupling of the versatile
boron-stabilized organozinc reagent BpinCH2ZnI with a racemic
branched allylic carbonate has been developed here, which differs
from our previous work by using 1,1-bisborylmethane through the kinetic
resolution process. The reaction has a broad substrate scope, and
various chiral homoallylic organoboronic esters could be obtained
in good yields with excellent enantioselectivities. The synthetic
practicability of the products was demonstrated by their conversion
to other useful families of compounds.