posted on 2023-12-31, 14:04authored byJianpeng Cai, Guohui Zeng, Kai Jiang, Hui Luo, Biaolin Yin
A protocol for the intramolecular reductive coupling
of unactivated
arenes with unactivated alkenes has been developed with the aid of
a cooperative visible light/cobalt catalytic system. This coupling
is achieved via radical cascade cyclization using amines as terminal
reducing reagents and water as the main hydrogen source. In their
form, readily available N-allyl benzamides are converted
to the corresponding spiro cyclohexadiene-lactam or β-phenethylamine
analogues in moderate to excellent yields.