Integration of IL6 receptor in the network.

sIL6RA could be removed since sIL6RA is the soluble form of IL6RA, and both share the same interactions with the rest of the network. CNTF receptor is a component of gp130 and they both share the same interactions with the rest of the network; therefore CNTF receptor was removed. In addition, gp130 and IL6RA/sIL6RA are components of IL-6 receptor. All regulators of gp130 or IL6RA also regulate the IL-6 receptor. The network was thus simplified by removing IL6RA, sIL6RA and gp130. IL-6 receptor activates STAT1, while its components gp130/CNTF receptors have an unclear effect on the same TF. Again, the most direct regulation was kept, namely STAT1 activation by IL-6 receptor.

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