Influenza virus titer (log10 TCID50/mL) in individual patients with PA/I38T-substituted viruses.

Lee, Leo Y; Zhou, Jie; Koszalka, Paulina; Frise, Rebecca; Farrukee, Rubaiyea; Baba, Keiko; Miah, Shahjahan; Shishido, Takao; Galiano, Monica; Hashimoto, Takashi; Omoto, Shinya; Uehara, Takeki; Mifsud, Edin J.; Collinson, Neil; Kuhlbusch, Klaus; Clinch, Barry; Wildum, Steffen; Barclay, Wendy S.; Hurt, Aeron C.

doi:10.1371/journal.ppat.1009527.s004

ppat.1009527.s004.docx (24.34 kB)

Influenza virus titer (log₁₀ TCID₅₀/mL) in individual patients with PA/I38T-substituted viruses.

journal contribution

posted on 2021-05-06, 17:55 authored by Leo Y Lee, Jie Zhou, Paulina Koszalka, Rebecca Frise, Rubaiyea Farrukee, Keiko Baba, Shahjahan Miah, Takao Shishido, Monica Galiano, Takashi Hashimoto, Shinya Omoto, Takeki Uehara, Edin J. Mifsud, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Steffen Wildum, Wendy S. Barclay, Aeron C. Hurt

Time course of influenza virus titer of individual baloxavir-treated patients with PA/I38X-substituted viruses, determined by TCID₅₀ assay (values below LLOQ were set at 0.7 log₁₀ TCID₅₀/mL). The black and red arrowheads indicate the sampling time-points for WT viruses (pre-baloxavir treatment for type A viruses and post-baloxavir treatment for type B virus) and PA/I38T-substituted viruses (post-baloxavir treatment), respectively. Black dotted line = LLOQ at 0.7 log₁₀ TCID₅₀.

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