pntd.0011639.s007.docx (551.55 kB)
Individual serological data after oral vaccination of goats and foxes.
journal contribution
posted on 2024-02-26, 18:42 authored by Magdalena Murr, Conrad Freuling, David Pérez-Bravo, Christian Grund, Thomas C. Mettenleiter, Angela Römer-Oberdörfer, Thomas Müller, Stefan FinkeGoats and foxes were directly orally vaccinated with either parental rNDV (n = 3) or RABV G expressing rNDV_GRABV (n = 6). Serum was taken from all animals at indicated days after vaccination (dpv) and analyzed for antibodies specific to RABV by a competitive ELISA (cELISA; seropositivity: inhibition ≥ 40%) and the fluorescent focus inhibition test (RFFIT; seropositivity: IU/mL ≥ 0.5). Serum was analyzed for antibodies specific to NDV by a competitive ELISA (cELISA; seropositivity: inhibition ≥ 40%) and the hemagglutination inhibition (HI) assay (seropositivity: log2 ≥ 3). Seropositive samples are highlighted in green, indeterminate samples in orange.
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sup >< bstrain clone 30pharyngeal lymph nodesreach spillover speciescarnivore species susceptibleviral rna couldsub >< bvirus neutralizing antibodieswildlife reservoir speciesdirect oral applicationinfectious ndv coulddiv >< psingle oral applicationempty viral vectorthree animals receivedreservoir speciesviral sheddingvaccinated animalssingle dosevirus replicationoral vaccinesoral immunizationtransgene expressiontest immunogenicitysub xmlnssimilar doseseven daysrndv ).representing herbivorenovel potentnasal swabsmammalian cellskey componentimmune responseglobal fightcell activity
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