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Inactivating point mutations in the GAP-like domain render ARHGAP36 cytosolic.

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posted on 2021-05-17, 17:26 authored by Patricia R. Nano, Taylor K. Johnson, Takamasa Kudo, Nancie A. Mooney, Jun Ni, Janos Demeter, Peter K. Jackson, James K. Chen

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    ARHGAP 36 isoformsRho GTPase-activating proteinnovel ARHGAP 36 antagonistC-terminal domainN-terminal autoinhibitory motifactivates Gli transcription factorsprolyl oligopeptidase-like proteinsites modulates ARHGAP 36 recruitmentisoform-specific N-terminal sequencessequencing-based mutagenesis screenARHGAP 36 regulationARHGAP 36C-terminal domains ARHGAP 36ARHGAP 36 structure-activity landscapeGAP homology domain

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