Immunohistochemical study by monoclonal antibodies CD8, CD4 PD-1 and PD-L1 for 8 primary and 11 metastatic tissues.

Sakimura, Shotaro; Nagayama, Satoshi; Fukunaga, Mitsuko; Hu, Qingjiang; Kitagawa, Akihiro; Kobayashi, Yuta; Hasegawa, Takanori; Noda, Miwa; Kouyama, Yuta; Shimizu, Dai; Saito, Tomoko; Niida, Atsushi; Tsuruda, Yusuke; Otsu, Hajime; Matsumoto, Yoshihiro; Uchida, Hiroki; Masuda, Takaaki; Sugimachi, Keishi; Sasaki, Shin; Yamada, Kazutaka; Takahashi, Kazuki; Innan, Hideki; Suzuki, Yutaka; Nakamura, Hiromi; Totoki, Yasushi; Mizuno, Shinichi; Ohshima, Masanobu; Shibata, Tatsuhiro; Mimori, Koshi

doi:10.1371/journal.pgen.1009113.s003

pgen.1009113.s003.pdf (732.66 kB)

Immunohistochemical study by monoclonal antibodies CD8, CD4 PD-1 and PD-L1 for 8 primary and 11 metastatic tissues.

journal contribution

posted on 2021-01-21, 18:25 authored by Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi Mimori

We validated that the immune exhaustion has been observed in CD8 expressing T cell in CRC tissues.

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