pgen.1009407.s010.docx (14.54 kB)
Identified genetic interactions between αSyn and Tet-alleles of essential genes.
journal contribution
posted on 2021-03-03, 18:40 authored by Blagovesta Popova, Dan Wang, Christina Pätz, Dagmar Akkermann, Diana F. Lázaro, Dajana Galka, Miriam Kolog Gulko, Markus T. Bohnsack, Wiebke Möbius, Katherine E. Bohnsack, Tiago F. Outeiro, Gerhard H. BrausThe first column indicates the standard gene name. The second column indicates the human orthologs. Type and strength correspond to observed genetic interactions in spotting assays after downregulation of the essential genes resulting in synthetic-sick (-) phenotype (protective gene) or growth enhancement (+) phenotype (drug target). Brief description of the protein function is deduced from the Saccharomyces genome database (SGD). Genes were classified in one functional category according to their function or biological process using Gene Ontology (GO) annotations, generated by Saccharomyces Genome Database (SGD) Gene Ontology Slim Mapper, FunSpec webserver and manual curation.
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