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Highly Localized SERS Measurements Using Single Silicon Nanowires Decorated with DNA Origami-Based SERS Probe
journal contribution
posted on 2019-01-08, 00:00 authored by Ardeshir Moeinian, Fatih N. Gür, Julio Gonzalez-Torres, Linsen Zhou, Vignesh D. Murugesan, Ashkan Djaberi Dashtestani, Hua Guo, Thorsten L. Schmidt, Steffen StrehleSurface
enhanced Raman spectroscopy (SERS) measurements are
conventionally performed using assemblies of metal nanostructures
on a macro- to micro-sized substrate or by dispersing colloidal metal
nanoparticles directly onto the sample of interest. Despite intense
use, these methods allow neither the removal of the nanoparticles
after a measurement nor a defined confinement of the SERS measurement
position. So far, tip enhanced Raman spectroscopy is still the key
technique in this regard but not adequate for various samples mainly
due to diminished signal enhancement compared to other techniques,
poor device fabrication reproducibility, and cumbersome experimental
setup requirements. Here, we demonstrate that a rational combination
of only four gold nanoparticles (AuNPs) on a DNA origami template,
and single silicon nanowires (SiNWs) yield functional optical amplifier
nanoprobes for SERS. These nanoscale SERS devices offer a spatial
resolution below the diffraction limit of light and still a high electric
field intensity enhancement factor (EF) of about
105 despite of miniaturization.