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Heterologous neutralization.

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posted on 2021-08-25, 17:39 authored by Jelle van Schooten, Marlies M. van Haaren, Hui Li, Laura E. McCoy, Colin Havenar-Daughton, Christopher A. Cottrell, Judith A. Burger, Patricia van der Woude, Leanne C. Helgers, Ilhan Tomris, Celia C. Labranche, David C. Montefiori, Andrew B. Ward, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Shane Crotty, George M. Shaw, Marit J. van Gils

A selection of neutralizing antibodies were assessed for their neutralizing activity against a panel of heterologous viruses representing global HIV-1 diversity. None of the mAbs were able to neutralize any of these viruses indicated by the IC50 value of >100 μg/mL.

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    PLOS Pathogens

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    prolonged antigenic stimulationinduce better responsesdiverse epitopes comparedanalyzing monoclonal antibodiesincreased antigen diversityinduced antibody responsesenv ), includingdiv >< pantibody responses induced1 envelope trimersstudying bnab developmentinform vaccine designprototypic bg505 sosipshiv infection resultedsoluble native hivbg505 shiv infectionbg505 sosip immunizationsoluble nativesosip designantibody responseextreme diversitybnab responsebg505 shivbg505 sosipshiv infectionbg505 envsosip immunizationnatural infection1 infectionvirus membranevaccine needsvaccine candidatesshown promisesequence isolatedplaced ontonatural hivmabs ).like hivlatter settinginfected infantinfected animalsimmunized animalshuman primatesextent vaccineenv either elicitedclonal expansionautologous virusanimal models664 immunogen1 ’

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