pgen.1011060.s008.pdf (287.81 kB)
Growth of ten-fold serial dilutions of M. abscessus ATCC 19977, ΔMabsigH, and ΔMabsigH complemented with either MAB_3543c, MAB_0827, MAB_1528c, MAB_3016c, MAB_4663, MAB_4748c or MAB_2739c on Middlebrook 7H10 plates containing indicated concentrations of AMK, TIG and STR.
journal contribution
posted on 2023-12-06, 18:35 authored by Kelley Hurst-Hess, Charity McManaman, Yong Yang, Shamba Gupta, Pallavi GhoshData is representative of >3 independent experiments.
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observed hypersensitivity δmabmajor hub controllingwhib7 functions exclusivelymycobacterium abscessus gene expression withinabscessus genes withinwhib7 demonstratingwhib7 transcriptional activatortargeting antibioticsresults suggestpromoters recognizedpresent workpoorly understoodmajor roleknown determinantsintrinsically resistantinterconnected networksinduced expressionindividual contributionshowever unknownhflx erm41 eis2 cumulative effectantibiotics effectiveantibiotic stress
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