ppat.1012050.s001.pdf (98.14 kB)
Growth curves of L2 Mtb clinical isolates with the indicated lldD2 alleles.
journal contribution
posted on 2024-02-29, 18:55 authored by Sydney Stanley, Xin Wang, Qingyun Liu, Young Yon Kwon, Abigail M. Frey, Nathan D. Hicks, Andrew J. Vickers, Sheng Hui, Sarah M. FortuneEach dot denotes the average of three technical replicates, the bars represent the standard deviation. The p-value indicates the results of ordinary-one way ANOVA tests conducted at each time point for each media condition, comparing the OD600 of the ancestral and variant strains. Sidak’s multiple comparison correction was performed.
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providing experimental evidencediv >< pcentral carbon metabolism1 virulence systemmycobacterium tuberculosis discernible growth defectdependent antibiotic susceptibilitymutations functionally increasehuman host environmentglobal clinical isolateslactate dehydrogenase revealsassessing mtb genes13 clinical isolatesvivo mtb growthlactate dehydrogenaseintracellular environmenthost pressuregenes involveddependent lvariation acrosstranscriptionally sensitivesugar phosphatesstrongest targetsstepwise natureselective advantagesalient featurerobust incorporationprovides contextpressures facingpoorly characterizedpleiotropic effectsmycobacterial cellmultifunctional rolemtb genomelldd2 lactate accumulationfunctional reporterdetoxification benefitdeleterious buildupdefining mutationsdata illustratebacterial determinantsbacterial adaptionancestral lineage
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