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Generation of a novel murine line combining the SARS-CoV-2 sensitive K18-hACE2 transgenic mice with Batf3-/- mice.

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posted on 2023-12-27, 18:31 authored by Liat Bar-On, Hani Dekel, Moshe Aftalion, Theodor Chitlaru, Noam Erez

The resulting hACE2 (blue) and hACE2/Batf3KO (red) littermates, identified by PCR-assisted genotyping of tail DNA samples, were used for infection experiments.

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    novel murine linefuture vaccine designdraining lymph nodealso significantly impactedwhereas humoral responses2 susceptible k18xlink "> sarsconsequent impaired cd8batf3 deficient micedependent dendritic cells2 viral load2 specific cd8specific cd8severely impairedregulating cd8dependent dccell responsesspecific role2 infectionsignificant increaseresults underscoreregulating sarsmay contributelargely unknownindependently corroboratedhace2 transgenicessential roleeffector phasecell responsecell immunityadditional covidadapted sars

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