pgen.1009571.s012.pdf (558.58 kB)
GTEx version 7 comparisons of single-tissue and multi-tissue imputation models using GEUVADIS LCL RNA-Seq expression as validation.
journal contribution
posted on 2022-01-31, 18:36 authored by Andrew E. Liu, Hyun Min KangCounts (B-H counts) are based on Benjamini-Hochberg procedure false discovery rate of 0.05. The last column displays the number of counts at p-value threshold 0.05 (without any corrections).
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unravel regulatory impactssingle reference cohortlarge eqtl studyeffective sample sizedepression susceptibility genescombines arbitrary numberregulatory variants identifiedimpute expression levelstraining imputation modelscombined 49 tissueexpression data acrossintegrating multiple tissuestested imputation accuracyimputation accuracy giventranscriptome imputation modelsleverage multiple tissuesmultiple tissuestissue expressionlevel datagenetic variantsgene expressioncannot leveragetranscriptome imputationimputation methodtissue typetarget tissuespecific tissuestraightforward approachshared eqtlsresults capitalizeproposed methodpowerful methodoptimal wayoften imputedmodel trainedlinearly optimizelevel statisticslevel genotypesexternal resourcesexisting jointalso extend
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