pone.0287496.s004.docx (208.6 kB)
Funnel plot of instrument precision against instrumental variable estimates for each genetic variant separately for Mendelian randomization analysis of exposure on outcomes risk.
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posted on 2024-02-07, 18:28 authored by Youqian Zhang, Zitian Tang, Yong Shi, Lin Li(A) AS intake in coffee on T2DM (B) AS intake in tea on T2DM (C) AS intake in cereal on T2DM (D) T2DM on AS intake in coffee (E) T2DM on AS intake in tea (F) T2DM on AS intake in cereal. Solid vertical line is the (random-effect) inverse-variance weighted estimate.
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three validation techniquessignificant evidence suggestedprimary method adoptedlinkage disequilibrium scoreinvestigate confounding factorsinverse variance weightedfalse discovery ratediabetes genetics replication002 – 0001 – 0ivw ), complemented>< sub ><035 – 1significant genetic correlationartificial sweetener intake004 – 0012 ), cerealreverse mr analysisldsc analysis unveiledgenetic correlationartificial sweetenersfdr ),012 ),>mr analysist2dm ),xlink ">various sourcesuk biobanksensitivity analysespositive correlationidentified (<fdr different sourcescausal relationshipcausal link049 ).042 ).
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