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Functional propagation of perturbations.

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posted on 2024-01-12, 18:41 authored by Karan Kabbur Hanumanthappa Manjunatha, Giorgia Baron, Danilo Benozzo, Erica Silvestri, Maurizio Corbetta, Alessandro Chiuso, Alessandra Bertoldo, Samir Suweis, Michele Allegra

We simulated the propagation of a perturbation in the model where A is the average (over subjects) effective connectivity matrix. The system’s state was initialized to x(0) = 0 (corresponding to the stable equilibrium point) except for the state of node i that was perturbed to xi(0) = 1. We let the system evolve freely until t = 100. The signal of area j is the functional response of area j to the perturbation in i. (A) functional in all areas j ≠ 0 when node i = 0 is perturbed. (B) For each region (except the pertubed region i), we identified the time corresponding to the maximum of the functional response. We iterated this procedure perturbing all n regions in the network, obtaining n ⋅ (n−1)) response peak times. We show the histogram of peak response times. The average response time is T = 10.29.

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