posted on 2023-11-16, 07:13authored byDmitrii
V. Kalinin, Trond Ulven
A chemoselective Pd-mediated carbonylative Negishi-type
catalytic
protocol for the synthesis of (hetero)aryl ketones is reported. The
protocol employs the PEPPSI-IPr precatalyst and CO gas at atmospheric
pressure (balloon) to foster the carbonylative coupling between diverse
C(sp3)-hybridized organozinc reagents and a broad range
of aryl iodides, including substrates carrying aldehyde, aniline,
phenol, or carboxylic acid groups, and heteroaryls.