posted on 2022-12-09, 16:42authored byZhen Wang, Yu Miao, Qiang Ou, Ruo-Xin Niu, Yi Jiang, Chun Zhang
Full-color-tunable
hydrogels with ultrahigh stability
can be used
in various fields, including intracellular temperature sensing. However,
constructing full-color-tunable organic nanohydrogels with excellent
biocompatibility and stability for intracellular temperature sensing
remains a great challenge. Here, we report a full-color-tunable nanohydrogel
with ultrahigh stability as an intracellular nanothermometer. Three
types of temperature-sensitive polymers with red, green, and blue
fluorescence were synthesized. Through easy mixing of these three
polymers with regulation of the mass ratio, these polymers can be
encoded to full-color-tunable fluorescent nanohydrogels, including
nanohydrogels with white-light emission (NWLEs), with sizes of about
200 nm in aqueous media. Further study suggested that the as-obtained
NWLEs exhibited good performance in intracellular temperature sensing
because of their ultrahigh stability on their fluorescence properties
and morphologies.