pone.0259663.s004.docx (20.22 kB)
Frequency of APOE E4-positive individuals in each stratum based on genotype of each of the three functional variants of VC transporters.
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posted on 2021-11-15, 18:36 authored by Koji Hayashi, Moeko Noguchi-Shinohara, Takehiro Sato, Kazuyoshi Hosomichi, Takayuki Kannon, Chiemi Abe, Chiaki Domoto, Sohshi Yuki-Nozaki, Ayaka Mori, Mai Horimoto, Masami Yokogawa, Kenji Sakai, Kazuo Iwasa, Kiyonobu Komai, Mai Ishimiya, Hiroyuki Nakamura, Natsuko Ishida, Yukio Suga, Junko Ishizaki, Akihito Ishigami, Atsushi Tajima, Masahito Yamada(DOCX)
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database searches revealedapolipoprotein e e458 – 6252 cognitively normal05 – 554 dementia ).minor allele carriersmajor allele homozygoteslevel reduces apoe4div >< pdeveloping cognitive decline05 – 3vc transporter genesmajor allelecognitive declinesnvs ).respective geneshomozygote carrierssnv genotypeslc2a3 slc2a1 slc23a2 significantly associatedsignificant effectsignificant associationssignificant associationrisk factorresults implyrespective snvspresent studyp odds ratiofunctional variantsfunctional snvsbrain (<associated riskaltered expressionalso observedaffect apoe40012 ),
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