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First report on the chemical composition of leaf essential oil of Myrciaria pilosa Sobral & Couto and its antimicrobial and antivirulence activities against Staphylococcus aureus

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posted on 11.04.2022, 09:20 authored by Wêndeo Kennedy Costa, Nandara Ohana da Costa Gomes, Bruno Souza dos Santos, Clóvis Macêdo Bezerra Filho, Alisson Macário de Oliveira, Graziela Cláudia da Silva, Bruno Oliveira de Veras, Fernanda Granja da Silva Oliveira, Júlio César Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Maria Tereza dos Santos Correia, Márcia Vanusa da Silva

Myrciaria pilosa is a tree species of the Brazilian Caatinga biome. This paper is the first report on the chemical composition and the antimicrobial and antivirulence activities of essential oil extracted from its leaves. The oil was extracted by hydrodistillation. Chemical composition determined by GC–MS and CG–FID revealed 63 compounds; the sesquiterpenes guaiol (13.17%) and (E)-β-caryophyllene (11.26%) dominated. Antimicrobial activity against strains of Staphylococcus aureus was evaluated by the broth microdilution method. It showed minimum inhibitory concentrations (MIC) of 5 μg/mL against evaluated strains and minimum bactericidal concentrations (MBC) ranging from 10 to 20 μg/mL. Evaluation of antivirulence activity showed reductions of 92.0% and 47.2%, respectively, in haemolytic action and production of staphyloxanthin. These findings show that the essential oil of M. pilosa has potential as an antimicrobial drug to control infection by multi-resistant strains of S. aureus.