pbio.3002249.s013.docx (14.85 kB)
Final estimates for tecovirimat PK models in mpox-infected NHPs and uninfected humans used in our analysis.
journal contribution
posted on 2023-12-21, 18:25 authored by Bach Tran Nguyen, Aurélien Marc, Clara Suñer, Michael Marks, Maria Ubals, Águeda Hernández-Rodríguez, María Ángeles Melendez, Dennis E. Hruby, Andrew T. Russo, France Mentré, Oriol Mitjà, Douglas W. Grosenbach, Jérémie GuedjPK, pharmacokinetic; NHP, nonhuman primates; wt: weight; dose: dose level in mg/kg; IIV, interindividual variability; IOV, intra-occasion variability; NA, not available.
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54 untreated patientsestimated mpox withindrug steady statepositive viral culturepharmacological model developeddiv >< pviral dynamic modelcharacterize mpox kineticsviral kineticsmpox infectiondrug administrationviral peakmpox clearanceviral clearanceunique setsymptom onsetskin lesionsrecommended dosesnonhuman primatesmodeling frameworkinitiating treatmentinfection dayinfected cellsideally startinghealthy volunteersfindings supportearly administrationdespite usecould reduceantiviral effect2022 outbreak10 days0 log
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