Final estimates for tecovirimat PK/PD model in NHPs (N = 24).

Nguyen, Bach Tran; Marc, Aurélien; Suñer, Clara; Marks, Michael; Ubals, Maria; Hernández-Rodríguez, Águeda; Melendez, María Ángeles; Hruby, Dennis E.; Russo, Andrew T.; Mentré, France; Mitjà, Oriol; Grosenbach, Douglas W.; Guedj, Jérémie

doi:10.1371/journal.pbio.3002249.s012

pbio.3002249.s012.docx (14.37 kB)

Final estimates for tecovirimat PK/PD model in NHPs (N = 24).

journal contribution

posted on 2023-12-21, 18:25 authored by Bach Tran Nguyen, Aurélien Marc, Clara Suñer, Michael Marks, Maria Ubals, Águeda Hernández-Rodríguez, María Ángeles Melendez, Dennis E. Hruby, Andrew T. Russo, France Mentré, Oriol Mitjà, Douglas W. Grosenbach, Jérémie Guedj

PK/PD, pharmacokinetic/pharmacodynamic; NHP, nonhuman primate; RSE, relative standard error; μ, proportion of infectious virions; pT₀, number of virions produced from infected cells; δ, loss rate of infected cells; EC₅₀, tecovirimat concentrations inhibiting 50% of viral production; k_e0, drug transfer rate between plasma and effect compartments; ω_θ, interindividual variability on parameter θ; σ_add, additional error on viral load.