posted on 2021-06-22, 16:36authored byJing Zhao, Hong-Gui Huang, Weishuang Li, Wen-Bo Liu
An efficient aminochlorination reaction
of stryenes is described
using N3SO2CF3 as an amination reagent
and FeCl2 as a chloride source. The operationally simple
procedure features mild reaction conditions, good functional group
compatibility, and high regioselectivity. An example of aminobromination
using FeBr2 is also realized. Additionally, a one-pot aminoazidation
of styrenes is achieved by adding sodium azide to the reaction. The
gram-scale synthesis and downstream derivatization of the products
are showcased as well.