pone.0253062.s001.pdf (867.87 kB)
FAK and laminB1 co-localize at the nuclear rim in shGFP expressing cells.
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posted on 2021-07-08, 17:32 authored by Varsha Thakur, Juliano Tiburcio de Freitas, Yuan Li, Keman Zhang, Alyssa Savadelis, Barbara Bedogni% co-localization: 3% +/- 0.07 (ImageJ). Cells transduced with an shRNA against MT1-MMP express low laminB1. % co-localization: 0% (ImageJ). Images were taken at 60X magnification. Each color channel was maintained at the same intensity for both shGFP and shMT1 cells.
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breast cancer cellsMT 1-MMPcancer patientslaminB 1Stable laminB 1FAKlaminB 1 expression rescues replica...mediates replication forkmatrix metalloproteinase MT 1-MMPbreast cancerreplication forkchemotherapy resistanceenvelope protein laminB 1MT 1-MMP inhibitionRF degradationDNA damagenovel mechanismMT 1-MMP ECM processinglaminB 1 stabilityreplication forksextracelluar matrixRF protection factors
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