posted on 2021-09-03, 16:07authored byErnesto De la Paz, Abbas Barfidokht, Samantha Rios, Christopher Brown, Edward Chao, Joseph Wang
An
effective, noninvasive glucose monitoring technology could be
a pivotal factor for addressing the major unmet needs for managing
diabetes mellitus (DM). Here, we describe a skin-worn, disposable,
wireless electrochemical biosensor for extended noninvasive monitoring
of glucose in the interstitial fluid (ISF). The wearable platform
integrates three components: a screen-printed iontophoretic electrode
system for ISF extraction by reverse iontophoresis (RI), a printed
three-electrode amperometric glucose biosensor, and an electronic
interface for control and wireless communication. Prolonged on-body
glucose monitoring of up to 8 h, including clinical trials conducted
in individuals with and without DM, demonstrated good correlation
between glucose blood and ISF concentrations and the ability to monitor
dynamically changing glucose levels upon food consumption, with no
evidence of skin irritation or discomfort. Such successful extended
operation addresses the challenges reported for the GlucoWatch platform
by using a lower RI current density at shorter extraction times, along
with a lower measurement frequency. Such a noninvasive skin-worn platform
could address long-standing challenges with existing glucose monitoring
platforms.