Examples of normalized sequence space coverage (NSSC) curves and the distribution of minimum NSSC.

(A) NSSC is plotted against k-mer length for eight genomes as an example: Homo sapiens, Gallus gallus, Dinoponera quadriceps, Theobroma cacao, Saccharomyces cerevisiae, Escherichia coli, Sorangium cellulosum, and Nanoarchaeum equitans (see Fig 3C for a schematic of idealized NSSC curves). Genome lengths varied widely, from ~0.5Mbp for N. equitans to ~3Gbp for H.sapiens. A histogram of the minimum NSSC for all 5805 genomes is shown in (B). The minimum NSSC usually occurs within the range 0.4–0.9 (0.668 ± 0.123 [mean ± STD]).

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