pone.0298788.s003.docx (16.13 kB)
Examples of drug pairs with inconsistent synergy scores across five cell lines.
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posted on 2024-02-23, 18:44 authored by Kittisak Taoma, Marasri Ruengjitchatchawalya, Monrudee Liangruksa, Teeraphan LaomettachitExamples of drug pairs with inconsistent synergy scores across five cell lines.
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line specific mutationsidentify distinct patternshighest single agenthighest pearson ’great balance amongfive different modesmodels reproduced celldiv >< pobserved synergistic effectsclustered drug pairsbreast cancer treatmentssynergistic effectsdrug treatmentsdrug pairsbreast cancersynergistic inhibitionsynergistic activationvast numbersilico signaling pathwaysshown potentialresponse behaviorspss provides directionprotein activitiesmechanistic understandingmechanisms underlyingintegrating informationgroups basedgene expressionexperimental datadrug combinationscorrelation coefficientcommon typesclassification metricschallenging dueboolean modelingapproach offers64 ).), determining
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